World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 6.842

ICV : 78.6

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SJIF Impact Factor: 6.842

Abstract

EFFECT OF SALVIA EGYPTICAE AND FOENICULUM VULGARA EXTRACTS ON QUORUM SENSING AND BIOFILM FORMATION OF METHICILLIN RESISTANT/SENSITIVE STAPHYLOCOCCUS AUREUS ISOLATES

Said E. Desouky*, Saad E. Hassan, Mamdouh S. El-gamal, Mohammed Abu Elghait Tamer I. M. Ragab, Mahmoud Emam

ABSTRACT

Staphylococcus aureus is a multidrug resistant Gram positive pathogen employing cyclic peptide-mediated quorum sensing (QS) system, termed agr which regulate the expression of a series of virulence genes including bacterial hemolytic activity. To identify quorum sensing inhibitors (QSIs) that target agr and also biofilm formation, random screening of medicinal plants extracts were examined with regard to Staphylococcal Isolates hemolysis. Promising extracts purified and fractionated using HPLC. As a result, semi-purified compounds SE7042-4 and FV7061-6 obtained from Salvia egypticae and Foeniculum vulgarai respectively, showed reduction of hemolysin production and biofilm formation of MRSA and MSSA isolates. Moreover, SE7042-4 attenuate production of gelatinase in E. faecalis in dose response manner without growth inhibitory activity.

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