World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 6.842

ICV : 78.6

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Abstract

REDUCED GRAPHENE OXIDE/GOLD NANOPARTICLES NANOCOMPOSITE MODIFIED GLASSY CARBON SENSOR FOR ELECTROCHEMICAL DETECTION OF MELPHALAN HYDROCHLORIDE

Abdulkareem Abdulraheem and Maha F. El-Tohamy*

ABSTRACT

Background: Our study described a new electrochemically modified reduced graphene oxide/ gold nanoparticles glassy carbon sensor for the electrochemical detection of melphalan hydrochloride. Method: The reduction behavior of melphalan hydrochloride on the surface of the modified sensor was evaluated using square wave adsorptive stripping voltammetry in the presence of phosphate buffer pH = 7. Results: Under optimum conditions (Scan rate 100 mV s-1, frequency 30 Hz, pulse amplitude 60 mV, accumulation potential - 0.2 V and accumulation time 360 s) the voltammogram of the investigated drug displayed an excellent peak current over a concentration ranging from 1.0×10-7-1.0×10-3 mol L-1, (r = 0.999) with detection/quantification limit ratio = 5.0×10-8/1.6×10-7 mol L-1. The developed method was validated and its precision was proved using inter-day and intra-day detection. Conclusion: The proposed analytical method was applied for the detection of the drug of interest in intact powder, its pharmaceutical injections and bio-samples. Acceptable results with excellent agreement with those reported from other previously recommended methods were obtained.

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