World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 6.842

ICV : 78.6

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Abstract

ACYCLOVIR – LOADED SOLID LIPID NANOPARTICLE BASED CREAM: A NOVEL DRUG DELIVERY SYSTEM

Mona Ibrahim Abdel Tawab Ahmed El-Assal*

ABSTRACT

Background Topical treatment of skin diseases needs to be strategic to ensure high drug concentration in the skin with minimum systemic absorption. The present investigation was enthused by the possibility to develop solid lipid nanoparticles (SLNs) of hydrophilic drug acyclovir. Also study vitro and vivo drug delivery. Methods: Acyclovir loaded solid lipid nanoparticles were prepared by high pressure homogenization of aqueous surfactant solutions containing the drug-loaded lipids in the melted or in the solid state with formula optimization study. Acyclovir loaded solid lipid nanoparticles were incorporated in cream base. The pH was evaluated and rheological study. Drug release was evaluated and compared with drug based on simple cream. Also the release of acyclovir loaded solid lipid nanoparticles conjugate with compritol 888ATO was compared with marketed cream. The potential of solid lipid as the carrier for dermal delivery was studied. Results: Particle size analysis of SLNs prove small, smooth, spherical shape particle ranged from 150 to 200 nm for unloaded and from 330 to 444 nm for acyclovir loaded particles. The EE% for optimal formula is 72% with suitable pH for skin application. Rheological behavior is shear thinning and thixotropic. Release study proved controlled drug release especially in formula containing compritol88 ATO. Stability study emphasized an insignificant change in the particles properties over 6 month. In-vivo study showed significantly higher accumulation of acyclovir in stratum corneum compared with blank skin. Conclusion: acyclovir loaded solid lipid nanoparticles might be beneficial in controlling drug release, stable and improving dermal delivery of antiviral agent(s).

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