Abstract

Shahad Abdullah AlMansour*, Alaa Sulaiman AlOqail, Shomoukh abdulrahman AlNashmi,
Rand Abdulrahman AlHaweal and Hayfa Saleh Alabdulkarim

ABSTRACT

Kawasaki disease is one of the common vasculitides in childhood. Many children worldwide are suffering from Kawasaki disease and many lines of treatment are currently given. In this review, we discussed IVIG, either with aspirin or corticosteroids, or even only corticosteroids. Since the quantity of the dose is very important, studies show that an initial high quantity is more efficacious than a low initial quantity by avoiding the non-response consequences, which can potentially lead to the formation of coronary artery lesion (CAL) and coronary aneurysms. Furthermore, the treatment is also time sensitive, which means that is important to be taken as early as possible and not after the beginning of the non-responsive state, and specifically until the 7th day of continuous fever. Other studies have also demonstrated that except of the time and quantity, the existence of not of certain polymorphisms can play an important role in the expression of the non-responsive state. In cases were the individual patient has reached his/her non-responsive state, it has been shown that IVIG is still effective and can decrease the formation of CAL and thus coronary artery aneurysms. So, in order to perform and achieve the better possible result, it is very important to take all the aforementioned steps into account.