Abstract

Nancy Dixit*, Avinash Gupta, Rajesh Asija and Manish Sharma

ABSTRACT

Lipids usually enhance drug absorption in the gastrointestinal tract (GIT), and when formulated as nanoparticles, these molecules improve mucosal adhesion due to small particle size and increasing their GIT residence time. Lipospheres are lipid based dispersion systems in which drug is dissolved or dispersed in lipidic core, the surface of which is embedded with emulsifier layer. The lipospheres are distinct from microspheres of uniformly dispersed material in homogenous polymer since they consist of two layers, the inner solid particle that contains the entrapped drug with phospholipids outer layer. Various Properties of lipospheres like film forming ability, occlusive properties; controlled release from solid lipid matrix resulting in prolonged release of drug and retarded systemic absorption of drugs; increasing the stability of drugs which are susceptible to extensive hepatic metabolism, make them attractive candidates for topical delivery.