UNUSUAL AND RARE PRESENTATION OF HYPOTHYROIDISM (HOFFMAN SYNDROME)
*Dr Mohd Younus Shah, Dr Sunny Goyal, Dr Saurabh Setia, Dr Gagandeep Singh, Dr Shaveta and Dr Taranpreet Singh Kocchar
ABSTRACT
The neurological manifestations of hypothyroidism are very unusual to see as initial symptoms and they usually occur late in the course of disease. Muscle hypertrophy is an extremely rare finding in hypothyroid patients. Hypothyroidism presenting as muscle stiffness and muscle pseudo hypertrophy in adults is known as Hoffmann's syndrome. Laboratory investigation in hypothyroid myopathy generally shows increased levels of muscle enzyme. The electrophysiological study may reveal features suggestive of myopathy, neuropathy or mixed pattern. The symptoms and also the serum levels of enzymes return to normal with hormone replacement therapy. We report a case of hypothyroidism with calf muscle hypertrophy.
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