World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 6.842

ICV : 78.6

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Abstract

IBUPROFEN INDUCED STEVEN JOHNSON SYNDROME

Manasa Bollampally*, Gaddam Praneeth and Ambati Prithi

ABSTRACT

Stevens Johnson Syndrome (SJS) is a hypersensitivity reaction characterized by skin rashes with hyperpigmentation and cutaneous target lesions involving blistering/erosions over face, trunk & limbs. The mortality rates of SJS/Toxic Epidermal Necrolysis (TEN) is ranging between 10% and 75 %. Nonsteroidal antiinflammatory drugs (NSAIDs), analgesic agents and nonsulfonamide antibiotics are associated with SJS/TEN is controversial.[5] Case report: A 2years old male child was admitted in hospital with chief complaints of swelling, discolouration of lips and skin lesion since 4 days. Flexon suspension (ibuprofen 100mg+ paracetamol 125mg) was used for fever. The condition was managed with Intravenous fluids, oral corticosteroids prednisolone, fusidic cream and liquid paraffin. Conclusion: Early identification and discontinuation of the causative drug is very important as it helps to avoid secondary infection and other complications.

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