Abstract

J. Viswanath, Dr. Chakrapani Cheekavolu*, Renu Dixit, S. Sankaraiah and P. Leela

ABSTRACT

Introduction: Cissus quadrangularis and Zingiber officinale rocs are the species widely used in folk medicine to treat osteoarthritis and hasten the fracture healing process. Present study to evaluate the body weight and synovial fluid volume in osteoarthritis conditions. Method: To determine the body weight and synovial fluid volume during the treatment of tested drugs in osteoarthritis induced rats. The body weight and synovial fluid volume of each rat was measured every week after 14 days of inducing osteoarthritis. The knee swelling was calculated based on synovial fluid volume by using vernier calliper scale. The tested groups are: Group-I-Control, Group II-Dexamethasone, Group III-Cissus quadrangularis linn-450 mg/kg; Group-IV-Zingiber officinale rocs-450 mg/kg; Group-V- Cissus quadrangularis linn+Zzingiber officinale rocs-450mg/kg. Results: All tested drugs were significantly reduced body weight and synovial fluid volume as compared to control group as follows: Group-III; Cissus quadrangularis linn (166.83± 0.941to145.16±0.941)(3.04±0.12to1.87±0.25*),Group-IV; Zingiber officinale rocs (165.33±0.160 to 146.5 ± 0.871)(3.02±0.09 to1.86 ± 0.16*), Group-V Cissus quadrangularis linn+ Zingiber officinale rocs (166.83 ± 0.941+145.16 ± 0.941)( 3.05 ± 0.14 to1.85 ± 0.07*). Conclusion: All tested group are showed significant reduction in body weight and synovial fluid volume. Significant reduction of synovial fluid volume in combination treatment of cissus quadrangularis linn+ zingiber officinale rocs where compared to indusial drug which is almost equal to that of standard drug.