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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.103

ICV : 78.6

Abstract

RECENT SYNTHESIS AND APPLICATIONS OF N- ARYL AMINES: A MINI REVIEW

Dr. A. A. Patil*, P. R. Jain and D. V. Nagarale

ABSTRACT

N- Aryl amines and heterocycles are an important class of compounds and are widely used as medicinal[1] as analgesic drugs, biological[2] and NHC chemistry. Some of the compounds have also been reported as antibacterial. N-Aryl heterocycles like imidazole, benzimidazole, benzotriazole, pyrazole and indazole serves as important building blocks in pharmaceuticals. Some of the N-heterocyclic moiety is also found in many bioactive natural products. In addition 1-aryl benzotriazole are useful intermediates in the synthesis of pyridoacridine and carbolin synthesis. Among the heterocyclics, N-aryl imidazole is widely studied because of its distinct biomedical properties like AMPA receptor antagonists. Transition metal mediated C-N bond formations are important fundamental transformations and are commonly used for N-arylation reactions by metals such as Pd, Cu/CuI, and Fe. Mostly C-N bond formed by copper mediated (Ullmann reaction) and Palladium catalyzed (Buchwald-Hartwig reaction) has received much attention. Recently, iron catalyzed N-arylation of N-nucleophiles with various copperchelating ligands such as 1,10-phenoanthroline and vicinal diamines. N-arylation with excess of bases (K2CO3, K3PO4, KOH) in polar solvents (DMF, DMSO) was used in various literatures.

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