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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.103

ICV : 56.51

Abstract

AN UPDATE ON THE CLINICAL USEFULNESS OF CRP, TNF- α, IL-6, NT- pro BNP, HOMOCYSTEINE AND LIPOPROTEIN (a) IN THE DIAGNOSTIC AND PROGNOSTIC EVALUATION OF CARDIO VASCULAR DISEASES

Dr. Swaminathan S.*, Rajeswari S. and Dr. Wasim Mohideen

ABSTRACT

In the evaluation and treatment of cardiovascular diseases, the routine measurement of lipid profile is being used for many years and even today is the first line of laboratory test used in CVD screening. However, extensive research in this filed has shown that 50% of patients who died due to cardiac arrest have normal lipid profile levels at the time of death. Hence, there may be many hidden, genetically linked inflammatory markers which may have caused such deaths and there is need to diagnose all cardiac dysfunction related patients by measuring markers like CRP, TNF-?, IL-6, BNP and Homocysteine and Lipoprotein (a) as studies have shown increased levels of these in many cardiac dysfunctional patients. This review article is an attempt to bring out the research findings during the last two decades on the clinical usefulness of the above markers and to recommend the measurements of these along with the traditional lipid profile so as to modify the treatment modalities and to evaluate the prognosis. Among the 6 markers reviewed in this article, while standardized methods with reference values are available for the first 5 parameters, methodological variations still exist for Lipoprotein (a) measurement and hence its clinical usefulness could be realised only after an acceptable method is established. The aim of this review article is to discuss the merits and better clinical usefulness of these additional biomakers which may facilitate fast and accurate diagnosis of CVD, heart failure and disorders associated with them.

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