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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.103

ICV : 78.6

Abstract

SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF NOVEL MANNICH BASE

S. Mohamed Rabeek, M. Sathyanarayanan and M. Seeni Mubarak*

ABSTRACT

In an effort to establish new candidates with improved antimicrobial activity of N-(4-chlorophenyl)-2,6-bis(3-nitrophenyl)-4-oxopiperidine-3-carboxamide was synthesized, characterized and evaluated for antimicrobial activity. The desired compounds was synthesized by the condensation of 4-chloroacetoacetanilide, 3-nitrobenzaldehyde with ammonium formate. Compound was characterized by IR, 1H-NMR, 13C- NMR and elemental analysis. They were also screened for antimicrobial activity against Klebsiella pneumonia, Staphylococcus auerus, Shigellady sentaeriae, Escheria coli, Pseudomonous aeruginosa, Streptococcus pneumonia and Proteus vulgaris.

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