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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.103

ICV : 78.6

Abstract

H.PYLORI ASSOCIATED CHRONIC GASTRITIS AND INTESTINAL METAPLASIA - A CLINICOSTATISTICAL AND HITOPATHOLOGICAL STUDY

Dr. K. Anbukkarasi* and Dr. P. Karkuzhali

ABSTRACT

Chronic gastritis has a high incidence in adults, causing progressive destruction of glandular structures, favoring the development of gastric atrophy. The association of chronic gastritis with intestinal type metaplasia of gastric mucosa has a poor outcome as intestinal metaplasia is regarded as a precancerous lesion. Metaplasia is common in patients with Helicobacter pylori infection. The aim of our study was to study chronic gastritis and its association with H.pylori and intestinal metaplasia. The study was conducted on a total of 800 patients, aged between 20 and 60 years, who presented for dyspeptic disorders in the period 2015–2016 and were examined clinically and endoscopically. During the gastroscopic examination, fragments of gastric mucosa were collected for the histopathological study and for detection of H.pylori infection. For the histopathological study, Hematoxylin–Eosin was performed, while for identifying H.pylori infection, giemsa stain was done. A diagnosis of gastritis was established in 390 patients, representing approximately 48.75% of all cases. Most cases with gastritis were found in people of middle age. Gastritis was present in almost all age groups. Of the 390 cases of gastritis, histopathological examination identified the presence of intestinal metaplasia in 45.64% of patients with chronic gastritis, and h.pylori positive was found in 51% of patients with chronic gastritis. This study highlights the association of chronic gastritis and H.pylori and the presence of intestinal metaplasia, which is a precancerous condition.

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