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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.103

ICV : 56.51

Abstract

EXPLORING THE COORDINATION CAPABILITIES, THERMAL AND ANTIMICROBIAL STUDIES OF 1-PHENYL-3-METHYL-4-BENZOYL-5-PYRAZOLONE N (4)- METHYL- N(4)-PHENYLTHIOSEMICARBAZONE

K. G. Sangeetha* and K. K. Aravindakshan

ABSTRACT

Transition metal complexes of an ONS donor ligand, 1-phenyl-3-methyl-4-benzoyl-5-pyrazolone, N(4)-methyl- N(4)-phenylthiosemicarbazone (H2L) were synthesised. The metal complexes were characterized by elemental analyses, magnetic susceptibility measurements, electronic, vibrational and 1H-NMR spectra. ESR spectrum of the copper(II) complex was recorded. Thermal stabilities of the complexes were also ascertained. The preliminary in vitro antimicrobial screening of the ligand, copper and zinc complexes were also performed. For this studies, four fungal strains, three Gram (-ve) and three Gram (+ve) bacteria were used. Complexes showed better microbial inhibition activity than the ligand.

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