World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 6.842

ICV : 78.6

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Abstract

EVALUATING THE ANTIMICROBIAL EFFICACY OF BIO PURE MTAD IN COMBINATION WITH NISIN AND DAPTOMYCIN IN PREVENTING ROOT CANAL INFECTIONS

S . Sree .Soumya *, B.G. Viswanath, Raji Viola Solomon, M.S Ranga Reddy

ABSTRACT

Successful root canal therapy relies on the combination of proper instrumentation, disinfection and obturation of the root canal. Of these three essential steps of the root canal therapy, disinfection of the root canal is a major determinant in the healing of the periapical tissues[1] Microorganisms play an essential role in the development of periradicular diseases and are the major causative factors associated with endodontic treatment failures.[2] Hence, proper debridement of the root canal system prior to obturation is an important step in achieving a successful treatment. There is a strong relationship between the long-term treatment success and root canal filled after negative culture in teeth with apical periodontitis. Studies reveal complete periapical healing in 94% of teeth with apical periodontitis that yielded negative culture after root canal instrumentation. In contrast, the samples with positive culture before root canal obturation had only 68% of complete periapical healing.[3] The microbiology of pulp cavity is of the most complex nature predominated mainly by anaerobic species commonly

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