TOTAL CHOLESTEROL AND HDL RATIO IN NORMOGLYCEMIC OFFSPRING OF PATIENT WITH T2DM ON GRADED EXERCISE
Dr. Taiwo E. O.*, Akindele R.A, Adefuye B.O., Sofola O.A., Fasanmade A. A, Oyebola D.D.O., Onyemelukwe G.C, and Osonuga I. O.
Objectives: The primary causes of Type 2 Diabetes Mellitus (T2DM) are largely unknown but increase in Total Cholesterol and HDL ratio (TC and HDL ratio) has been reported to be a risk factor for the T2DM through the alteration of Lipid Profile (LP). However, it is uncertain if exercise could influence the occurrence of T2DM in offspring of diabetic parents by altering the lipid profile. Therefore this study was designed to assess the effect of exercise on TC and HDL ratio in offspring of T2DM parents compared with offspring of non-diabetic parents. Design: This study involved selection of 42offspring of T2DM parents attending University College Hospital, Ibadan and 53 offspring of non-diabetic parents who are undergraduate students of the University of Ibadan, Nigeria.. Participants were randomly assigned into four groups; 27 Normal-weight Offspring of Non-Diabetic Parents (NONDP), 21 Normal-weight Offspring of Diabetic Parents (NODP), 26 Overweight Offspring of Non-Diabetic Parents (OONDP) and 21 Overweight Offspring of Diabetic Parents (OODP). Each participant followed a protocol of graded exercise using the tummy trimmer everyday spending 30-45 minutes daily for 24 weeks. Blood samples were obtained after an overnight fasting for determination of lipid profile levels at baseline, six week, 12 weeks, 18 weeks and 24 weeks, respectively.The LP determined from the fasting lipid Profile was measured spectrophotometrically using standard laboratory kits supplied by BIOLABO, France. Data were analyzed using descriptive statistic and student t test with significance at p<0.05. Results: After exercise, there were reductions in total cholesterol (mg/dL). There is reduction from 5.45±1.14 to 3.33±0.30 (p<0.05) in OODP from 3.85± 0.42 to 3.26±0.33(p=NS) in NODP from 4.01±0.31 to 3.07±0.16(p<0.05) in OONDP from 4.72±0.40 to 3.94±0.30(p<0.05) in NONDP. There were significant changes in TC and HDL ratio between baseline and at 24 weeks. Conclusions: Graded exercise reduced TC and HDL ratio in all the groups. The clinical importance of graded exercise in prevention of diabetes mellitus along with reducing lipid concentrations, among offspring of diabetic parents looks promising.[Full Text Article]