Abstract

Dr. Sareh Farhadi* and Maryam Kakuinejad

ABSTRACT

Aim & background: In spite of increase in the incidence of oral squamous cell carcinoma, there are not serious achievements gained in related treatment modalities and survival rates. Hence, through identifying the etiologic factors and the prognostic parameters, it is hoped that it would be possible to cure the lesions and reduce patients’ suffering and ailments. Human Papilloma Virus (HPV) might be one of the most important prognostic factors in oral cavity cancers. This study is an attempt to investigate & review of HPV prognostic role in oral squamous cell carcinoma. Methods & Materials: The investigated articles have been collected and studied meticulously using the data bases of PubMed, Medline, Scopus and Google Scholar through keywords of HPV, prognosis, survival rate, clinical outcome, oral cancer and OSCC during years of 2000 to 2015. Results: After scrutinizing and considering 23 articles, it was clarified that HPV-positive tumors can be treated easier. It can be related to some reasons such as more sensitiveness to therapies including chemotherapy and chemo radiation therapy .Furthermore, according to 12 articles, it was concluded that patients with HPV-positive tumors had higher survival rates compared with the HPV-negative ones, HPV-positive characteristic can be a significant prognostic factor. Conclusion: OSCC Patients presenting with HPV, have better prognosis and therapeutic response compared to those HPV-negative patients.