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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.103

ICV : 56.51

Abstract

SERUM SOLUBLE UROKINASE-TYPE PLASMINOGEN ACTIVATOR RECEPTOR (SUPAR) AND INTERLEUKIN-6 LEVELS IN ENDOMETRIOSIS

MD Dr. Raziye Desdicioglu*, MD Melahat Yildirim, MD Gamze Avcioglu, MD Emre Erdem Tas MD Özlem Şengul, MD Ozcan Erel and MD Ayse Filiz Yavuz

ABSTRACT

Introduction: The aim was to compare serum soluble urokinase plasminogen activator receptor (suPAR) and interleukin-6 (IL-6) levels between patients with and without endometriosis. Materials and Methods: Twenty two women with endometriosis and 25 healthy women were included in the study. Serum suPAR and IL-6 levels were assessed with the ELISA method. For statistical methods, t test and Receiver Operating Characteristic - ROC analysis were used. Results: Serum suPAR level was measured as 0.38±0.48ng/ml in the endometriosis group and as 0.16±0.11ng/ml in the control group (p<0.05). The interleukin-6 level was measured as 11.37±12.10 pg/ml in the endometriosis group and as 4.31±1.28 pg/ml in the control group (p <0.05). Conclusion: Serum suPAR and IL-6 levels were significantly higher in women with endometriosis. SuPAR may play a role as an inflammatory marker in the pathogenesis of endometriosis.

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