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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.103

ICV : 56.51

Abstract

COMPARISON STUDY OF AGERATUM CONYZOIDES LEAF EXTRACT WITH CONVENTIONAL MATERIALS WOUND COMPRESS TO INHIBIT OF S. AUREUS IN DIABETIC ULCERS

Asep Kuswandi* and Unang Arifin Hidayat

ABSTRACT

Background: Diabetic ulcer disease can lead to amputation by 40-70%. But with intensive care and have evidence based, can prevent amputation about 45-85%. If not prevented, there will be an amputation every 30 seconds (Consensus diabetes, 2008). Prevention is done such as by controlling the wound. There are many materials conventional to inhibit of S. aureus that cause of diabetic ulcers. Bandotan (Indonesia) (Ageratum conyzoideus) is one of number plants in Indonesia that used to wound healing as traditional medicine a long time. Aim:This study is aimed to compare different materials than conventional wound compresswith bandotan leaf extract. Methods: This research is a quantitative research in vitro design. Research variabel include 0.9% NaCl, 10% povidone, honey, gentamycin, glukobet (sugar and povidone mix), sugar, coffee and extracts bandotan. The cup that contains S.aureus was shelfed materials compress the wound. As a negative control plate is provided control and a positive control. Exposure to do three repetitions so that we will get an average area of the resistor. Results: 2.69% inhibition of honey, sugar 1.6 mm, 0.82 mm coffee, NaCl 0.9% of 0.00 mm, 10% povidone 1.67 mm, 2.47 mm glukobet, gentamycin in 0.9 % NaCl 2.39 mm and leaf extracts bandotan 10% was 4.08 mm. Conclusion: Bandotan leaf extracts have inhibitory wider than the other material compresses. Recommendation: Study further combination bandotan leaf, honey and sugar to obtain preparations that can be used to compress materials diabetic foot wounds.

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