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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.103

ICV : 56.51

Abstract

TO STUDY ANALGESIC AND ANTI-INFLAMMATORY EFFECT OF KARANJA (PONGAMIA PINNATA PIERRE) SEED CHURANA IN SWISS ALBINO MICE

Gupta Chandni* and Upadhayaya Ashwani

ABSTRACT

Objectives: The present study was carried out to evaluate 1) anti-inflammatory activity 2) analgesic activity, of the Karanja (Pongamia pinnata Pierre) Seed Churana Methods: To study anti-inflammatory activity carrageenin was used. The study was conducted in control group and test drug group at the dose 800mg and 1600mg/kg body weight. To study analgesic activity acetic acid induced writhing test was performed and values were observed in control and test drug group at different doses. Results: An apparent suppression of oedema formation was observed at both the dose levels. At 800 mg/kg dose level, 11.81% suppression of oedema was observed and it was statistically non- significant. At higher dose level (1600 mg/ kg), the suppression was 40.39% and it was statistically significant (p< 0.05). In lower test drug dose group (2.5 g/ kg), 34.06% decrease in number of acetic acid induced writhing was observed, while in higher test drug dose group (5.0 g/kg) 30.31% decrease was observed. However, both changes were found to be statistically non- significant. Conclusion: Karanja seed possess significant anti-inflammatory and weak peripheral analgesic activity.

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