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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.103

ICV : 56.51

Abstract

ASSESSMENT OF C-REACTIVE PROTEIN LEVELS IN NORMOTENSIVE AND HYPERTENSIVE PREGNANT SUBJECTS IN PORT HARCOURT, NIGERIA

Oladapo-Akinfolarin*, Tomaziga Tomiloba; Bartimeaus, Ebirien-Agana Samuel; Nwachuku, Edna Ogechi; Nduka Nsirim

ABSTRACT

Background: C-reactive protein (CRP) is a blood test marker for inflammation in the body whose levels rise in response to inflammation. The elevation has been linked to atherosclerosis. Because of the inflammatory component of atherosclerosis, elevated CRP levels have been linked with cardiovascular disease. Objective: To evaluate some cardiovascular disease risk status such as C-reactive protein in pregnant Normotensive and hypertensive pregnant women and compare it with the corresponding levels in non-pregnant normotensive women. Method: This study was conducted in the Department of Medical Laboratory Science, Rivers State University, Port Harcourt. Nigeria. A total of 300 women were registered for the study after taking informed conscent. 100 of them were pregnant hypertensives, 100 were pregnant normotensives and 100 non pregnant normotensives as control. All relevant information was recorded on a predesigned questionnaire. HsCRP levels were measured in the 200 normotensive and hypertensive pregnant women, including systolic and diastolic blood pressure, and BMI: and compared with that of the control. BMI was calculated as weight in kg divided by the square of height in metres. Result: Mean values of HsCRP between the two case groups and control were significant at p<0.05. Age, BMI, Systolic and Diastolic blood pressures were also significant at p< 0.05. BMI, Systolic and diastolic, and HsCRP were statistically significant when HPW were compared with NPW: Age, BMI, Systolic, diastolic and HsCRP were significant when HPW were compared with NNPW. Only BMI was significant when NPW was compared with NNPW. HsCRP was not significant .90% of HPW at 38.72±6.56, 14 % of NPW at 36.16±12.74, and 2% of NNPW at 31.38±0.88kg/m2 were obese. 58% of NPW at 27.24±1.34, 31% of NNPW at 26.78±1.40 and 10% of HPW at 27.41±1.14kg/m2 were overweight. 2% of NNPW at 17.20±1.23 were deficient, others were normal. HPW had the highest percentage of HsCRP for increased risk (62%) at 8.32±8.09, and the least percentage for low risk (7%) at 0.61±0.34mg/l. NNPW had the highest percentage for low risk(42%) at 0. 40±0.24mg/l and almost half of HPW for increased risk (32%) at 7.0±3.33mg/l. NPW had same percentage for high risk and low risk, ( 36%) at 7.03±4.51 and 0.31±0.33mg/l. 28% was recorded for moderate risk at 2.19±0.53mg/l using the different risk group categories. Conclusion: C-reactive protein as a marker of inflammation was elevated in normal pregnancy and further increased in hypertensive pregnant state.

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