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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.103

ICV : 78.6

Abstract

FLUORESCENT Mn(II) COMPLEXES OF HETEROCYCLIC SCHIFF BASES: CATALYTIC AND ANTIPROLIFERATIVE ACTIVITIES

A. K. Surabhi*, K. Pradeepkumar and M. R. Prathapachandra Kurup

ABSTRACT

Two novel fluorescent Schiff base ligands HL1 and H2L2.H20 derived from 2,6-diaminopyridine and their Mn(II) complexes were synthesized and physico-chemically characterized by means of partial elemental analyses, molar conductance measurements, magnetic susceptibility measurements and electronic, infrared, mass, EPR and 1H NMR spectral studies. In both the complexes, two molecules of ligands are octahedrally coordinated to Mn(II) ion. HL1 and H2L2·H20 respectively behave as monobasic and neutral ligands in coordination with metal ion. The two complexes were given the formula [Mn(HL1)2(H20)2] and [Mn(H2L2)2(OAc)2]·H20 respectively. The ligands and complexes exhibit enhanced blue fluorescence. The catalytic activity of these complexes was tested in the decomposition reaction of H2O2. These compounds show prominent anti proliferative activity. Highlights ? Synthesis and characterization of two novel ligands and complexes. ? High thermal stability of the complexes. ? Fluorescence property. ? Catalytic activity. ? Anti proliferative activity.

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