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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.103

ICV : 78.6

Abstract

PHOTOSTABILITY STUDIES OF NIFEDIPINE FOR PHOTOSTABLE COMPLEX IN DRUG DELIVERY SYSTEM

Dr. Mulchand A. Shende*, Rajendra P. Marathe and Deepak B. Adgaonkar

ABSTRACT

The present research work was to improve the physiochemical stability of nifedipine by complexation using weak cation-exchange resins, indion 234 to eliminate light decomposition tendency of drug. Resinate were prepared by batch process using various drug-resin ratio (1:1, 1:2, 1:4). Irradiation test for drug degradation was carried out by comparing pure nifedipine drug, methanolic drug solution and resinates to determine differences in the effectiveness of artificial light and natural indirect sunlight sources. Further, resinates were subjected to different in-vitro evaluation tests for loading of drug in resin, FTIR and DSC studies for confirmation of complex and in-vitro drug release study. The batch process of complexing nifedipine with Indion 234 (1:2) produced efficient drug loading. The efficacy of fluorescent light as compared to the tungsten lamp was found to be slightly more than fluorescent light. The nifedipine was degraded rapidly in methanolic solution form, slowly in powder form and very slowly in resinate form. Indion 234 was found to be better complexing agent for reducing the photosensitivity and help to design stable nifedipine in drug delivery systems.

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