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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.103

ICV : 78.6

Abstract

EVALUATION OF ANTI INFLAMMATORY EFFECTS OF BLUEBERRY (VACCINIUM) FRUIT EXTRACT IN WISTAR RATS : AN EXPERIMENTAL STUDY

Dr. Asha Jha* and Srimanti Paul

ABSTRACT

Background: Inflammation is a very common problem for physician consultation worldwide. Cyclooxygenase (COX) is involved in the development of inflammation and non-steroidal anti-inflammatory drugs (NSAIDs) represent one of the most common classes of medications used. Most of the NSAIDs are carboxylic acid and so cause severe side effects such as gastrointestinal ulceration, perforation, obstruction, and bleeding. In the recent years, the use of traditional medicine information on plant has again received considerable interest. One of the herbs, Blueberries, contains antioxidants which neutralize free radicals linked to the development of cancer, cardiovascular disease, and other age-related conditions. These berries contain anthocyanins, other polyphenols and various phytochemicals which are very good antioxidants. Blueberry contains polyphenols which attenuate inflammatory responses probably by reducing oxidative stress. The present study was undertaken to find a tasty and safe way to combat inflammations. Objectives of this study were to observe the effect of Blueberry on the volume of edema in a rat-paw-model and to compare this effect with that of Ibuprofen. Result: Vaccinium (Blueberry Fruit Extract) at the dose of 300mg/kg body weight was found to be prophylactic efficient on suppressing carrageenan induced acute inflammation in albino rats. Anti-inflammatory ability of Blueberry was found significant and comparable to Ibuprofen.

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