Abstract

Dr. Sareh Farhadi and Mehdi Mohamadi*

ABSTRACT

Aim and background: Oral squamous cell carcinoma (OSCC) is an invasive neoplasm that spreads either locally through regional lymph nodes or cause distant metastasis. Matrix metalloproteinase (MMP) degrades the extracellular matrices (ECMs) and have been thought to play an important role in both the invasion and metastasis of tumors. The aim of this study was to review the expression of MMPs in OSCC and explore the significance of MMPs expression in clinical outcome of these patients. Material and Methods: The most recognized data Bases such as PubMed, Google scholar, Science direct, etc. were searched using keywords as OSCC, MMP, prognosis, clinical outcome, prognosis, metastasis, invasion, stage and other related ones During 1999 to 2016. Results: Among 24 reviewed in this study, MMP-9 was reported in association with invasion, metastasis recurrence, prognosis and patient survival in 7 ones but in no association with survival in only 1 research. Also, it is reported MMP-2 incorporation with poor differentiation, invasion and metastasis of OSCC in 5 studies, MMP-7 in relation with biological behavior, invasion and metastasis in 3 ones, MMP-1and 10 as indicators of OSCC cancer risk and also potential oral cancer markers in 2 studies, MT1-MMP in association with prognosis and patient survival in 3 research and in relation with invasion and metastasis in only 1 study. 3 studies suggested MMP family was associated with prognosis and metastasis of OSCC. MMP 28 and 12 were also evaluated in 2 studies and researches could not find any correlation with them and any clinical evaluated parameters. Conclusion: Evaluation of the clinical data along with the expression of MMPs could be useful in predicting the post-therapeutic outcome and prognosis of OSCC patients. Furthermore, among members of MMP family, MMP 2,7 & 9 considered to association with clinical outcome and late evidences in oral cancerogenesis but MMP 1 & 10 might be related to early consequences occurred in this field as indicators or markers for initiation of OSCC.