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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.639

ICV : 78.6

Abstract

INVESTIGATION OF ANTIDIABETIC ACTIVITY AND ISOLATION OF COMPONENT FROM ETHANOL EXTRACT OF PROSOPIS STAPHANIANA

*Channapura Halappa Chandrashekhar, Kotehal Parameshwarappa Latha, Hosadu Manjappa Vagdevi

ABSTRACT

Background: The different parts of the Prosopis were being used in Ayurveda for curing various diseases. e.g. leaf for skin-bites and scorpion stings and bark for leprosy, dysentery and rheumatism. Very less research has been done on the plant Prosopis staphaniana and no publication has been found on antidiabetic activity. Objectives: This work is therefore contemplated to investigate Prosopis staphaniana for antidiabetic activity by alloxan induced diabetic model by using albino rats (Wistar strain) and insulin as standard. Methodology: The bark of the plant were washed and air-dried to get a constant weight, cut into small pieces and pulverized to powder using pestle and mortar to get a powder The ethanol extract was subjected column chromatography obtained fractions were treated for antidiabetic activity. Results: Significant (Sig. P <.005, HS. n = 6) dose-dependent effects were observed columned fractions of bark of Prosopis staphaniana. The results revealed that ethanol extract is having considerable diabetic activity. Ethanol extract was subjected to purification and isolated the new fattyacid. Conclusions: The results of this study revealed that the ethanol bark extract of of Prosopis staphaniana possesses antidiabetic activity through its phytochemical components.

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