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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.103

ICV : 78.6

Abstract

SIMULTANEOUS ESTIMATION OF NORFLOXACIN AND TINIDAZOLE IN SOLID DOSAGE FORM BY U V SPECTROPHOTOMETRY USING MIXED SOLVENCY CONCEPT

Sanjay Jain* R. K. Maheshwari Rajesh Kumar Nema, Indrajeet Singhvi

ABSTRACT

In present research work a new simple, specific, precise, accurate, robust and economical UV-Spectrophotometric method for simultaneous estimation of norfloxacin and tinidazole in tablet dosage form using mixed solvency concept was developed and validated. In the present work 10% phenol and 20% sodium benzoate blend was used as a hydrotropic solvent to increase the solubility of poorly water soluble norfloxacin and tinidazole. The analytical wavelength for norfloxacin and tinidazole are 323nm and 318 nm respectively. The developed method was validated as per ICH guidelines in terms of linearity and range, specificity, accuracy, precision and sensitivity. The percent drug estimated in tablet formulation was 95.20±0.448 for tinidazole and 97.00±0.599 for norfloxacin by method B. and similarly it was 97.10±0.514 for tinidazole and 95.26±0.394 for norfloxacin by method A respectively. The range of percent recoveries varied from 95.62±0.209 to 96.99±0.309 for tinidazole and 95.33±0.114 to 98.15±1.5 for norfloxacin. Based on the results obtained the proposed method can be regarded a simple, precise, accurate, reliable, cost effective and eco-friendly for simultaneous estimation of norfloxacin and tinidazole.

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