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World Journal of Pharmaceutical
and Medical Research

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 4.639

ICV : 78.6

Abstract

ROLE OF MRI IN EVALUATION OF NEUROLOGICAL DYSFUNCTIONS ASSOCIATED WITH ACUTE FEBRILE ILLNESS

Dr. Anagha Rajeev Joshi, Dr. Sujay Jaysing Salve and Dr. Ankita Ujjwal Shah*

ABSTRACT

Objectives: Many cases of acute febrile illness show neurological complications of not only diseases with known nervous system affliction like cerebral malaria; but also of diseases which were previously not thought to be neurotropic like Dengue fever. Our study has described the various abnormalities in MRI Brain scans of these patients. Methods: A prospective study of 34 patients, who presented with acute onset of fever and some form of neurological dysfunction, underwent MRI of Brain on an elective basis. Results: Of the 34 patients, 25 (74%) had abnormal MRI scans and 9 (26%) had normal scans. The final diagnosis of patients were as follows- Acute pyogenic meningitis. (8 patients- 23%), Cerebral malaria (7 patients- 21%), Dengue encephalitis (7 patients- 21%), Leptospirosis (2 patients- 6%), Viral encephalitis of unknown etiology (2 patients- 6%), Japanese encephalitis (1 patient- 3%), HSV encephalitis (2 patients- 6%), Influenza associated encephalitis (1 patient- 3%), CNS Tuberculosis (2 patients- 6%). In 2 patients, a diagnosis could not be established even after extensive diagnostic work-up. Conclusion: In acute fever associated with neurological dysfunction, MRI brain has a good sensitivity, however, there are doubts about its specificity in conclusively diagnosing specific diseases.

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