World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 6.842

ICV : 78.6

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Abstract

THE LONG-TERM OUTCOME OF CYCLOPHOSPHAMIDE ORAL VERSUS INTRAVENOUS IN CHINESES CHILDREN WITH STEROID DEPENDENT NEPHROTIC SYNDROME

Qinqin Zhao, Anupama Kumari Yadav and Hongzhu Lu*

ABSTRACT

Objectives: To investigate the effects of oral or intravenous cyclophosphamide with steroid dependent nephrotic syndrome(SDNS) children. Method: Sixty-nine SDNS children(39 girls and 30 boys) aged 1 to 14 years were treated with prednison and oral cyclophosphamide(OCP)(35cases) or with prednison and intravenous cyclophosphamide(IVCP) (34 cases). Essential investigations were done including blood count, renal function test, electrolytes, liver function test and Creatine-kinase isoenzyme(CK-Mb), Purified Protein Derivative(PPD), X-ray chest and urine analysis. Data were analyzed using appropriate SPSS 13.3 software for statistical test. Results: There were no statistically significant difference in children in two groups in age, sex, blood count, hemoglobin level, renal function, electrolytes, proteinuria, serum protein, albumin, cholesterol. Duration of remission were same in patients treated with IVCP and OCP. Side effects in patients treated with OCP were more than that in IVCP. Conclusion: The effects are similar in two groups, but side effects of OCP group are more than that in IVCP group. IVCP is a useful method for the SDNS children.

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