Abstract

Wadile Pawan Mohan, Ms. Sulbha G. Patil, Dr. S. P. Pawar

ABSTRACT

Ethosomes are novel lipid-based vesicular carriers created for improved transdermal drug delivery. Ethosomes are mainly made up of phospholipids and elevated levels of ethanol. noted for their capacity to infiltrate the skin's stratum corneum more efficiently than conventional liposomes. This distinctive characteristic is linked to ethanol's capability to fluidify the lipid. bilayers, promoting enhanced drug penetration into the skin layers. Ethosomes provide numerous benefits, such as enhanced bioavailability of therapeutic compounds, precise delivery, and minimized adverse effects. They have demonstrated potential in several applications, ranging from providing systemic medications for addressing localized issues. This summary outlines the formulation and mode of action, and possible uses of ethosomes, emphasizing their significance in improving transdermal drug delivery systems. The aim of this study was to develop and assess topical Methotrexate-loaded ethosomal gel, an effective antimetabolite and chemotherapy drug commonly employed in the therapy of different cancers and autoimmune disorders, including rheumatoid arthritis by reducing immune system activity, manages psoriasis by inhibiting growth of skin cells and addresses cancer by inhibiting the proliferation of cancer cells.