Abstract

Dr. Iqra Naeem, Dr. Muhammad Ovais Zafar, Dr. Khurram Irshad and Dr. Muhammad Irfan Jamil*

ABSTRACT

Background: The etiologies and clinical outcomes of acute kidney injury are variable throughout the world and has become important cause of morbidity and mortality in developing countries. Current study was planned to establish etiology, clinical profile and outcome of AKI among young patients in our hospital. Methods: It is a clinical, prospective observational study done in young patients aged 15 to 40 years, from July 2017- August 2018. 98 patients diagnosed clinically and according to RIFLE criteria were enrolled in the study and followed for 3 months to see outcome of disease. Results: Total 98 diagnosed patients were selected with age ranges from 15 to 40 years. Most of them were female 62/98 (63.2%). Clinical picture at the time of presentation was oliguria/anuria in 91%, hypertension in 40%, edema in 77.1%, nausea in 59.1%, anemia in 30.61%. Most common causes were obstetric (PPH/APH) in 30/98 (30.61%), sepsis in 13/98 (13.1%), obstructive urolithiasis in 16/98 (16.2%), paraphenylene diamine intake in 9/98 (9.1%), gastroenteritis in 8/98 (8%). Overall pre-renal causes were more frequent 56/98 (57.1%). In first encounter with our hospital most of the patients were in failure category according to RIFLE criteria 67/98 (68.3%). About 55/98 (56.12%) needed dialysis support. About 64.2% of the patient recovered. The mean duration of recovery was 16.4±26.7 days. Out of 98 patients, 18 developed CKD, 10 patients ended up as ESRD and mortality rate was 4/98 (4.09%). Conclusion: Leading causes according to our study were obstetrics, urolithiasis, and paraphenylene diamine. Patients with late presentation ended up with poor outcomes. A very handsome percentage of patients recovered in our study.