CORRELATION OF CHROMOSOMAL ABERRATIONS WITH MULTIORGAN DYSFUNCTION IN PERINATAL ASPHYXIA
A. Manoj*, B. Vishnu Bhat, C. Venkatesh, Z. Bobby
ABSTRACT
The current study evaluated oxidative stress induced DNA damage and chromosomal aberrations on multiorgan dysfunction in perinatal asphyxia. Eighty term asphyxiated babies were recruited in this study and all of them had organ dysfunction. Conventional Cytogenetic screening test was used for identification of chromosomal aberrations. Oxidative stress was assessed by estimation of serum MDA level. Chromatid breakage, dicentric chromosomes, inter chromatid connections, ring chromosomes and acentric chromoses were recorded.. The chromosomal aberrations in two, three, four and five systems were 2.75± 0.942072, 3.052632±0.998614, 3.25±1.409787 and 4.85±0.726292 respectively. Chromosomal aberrations increased with severity of asphyxia and it was well associated with oxidative stress (p
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