ACUTE RECURRENT ISOLATED BULBAR PALSY WITH ASYMMETRY A RARE VARIANT OF GUILLAIN- BARRÉ SYNDROME ASSOCIATED WITH ANTIGM3 AND ANTIGT1B ANTIBODIES OF IGG AND IGM SUBCLASS.
Dr. Sandhya Manorenj*, Dr. Snehalata Inturi and Dr. Jyotsna B.
ABSTRACT
Isolated bulbar palsy is a rare variant of Guillain-Barre Syndrome (GBS). Recurrence is even more rare. Antibodies against membrane proteins like GM3 and GT1b have been found only in few patients with GBS variant. Lack of free availability of antibodies and cost effectiveness of test makes diagnostic challenge in developing country like India. We describe a 29 year-old female presenting with acute isolated bulbar weakness with recurrence and asymmetry involving IX, X, and XI cranial nerves with normal reflexes and without limb weakness. Serological testing for antiganglioside antibodies was positive for both IgG and IgM anti-GM3 and antiGT1b antibodies, suggesting the association of these antibodies with isolated bulbar palsy.
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