World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 6.842

ICV : 78.6

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SJIF Impact Factor: 6.842

Abstract

THERAPEUTIC EFFECT OF VISCUM ALBUM AGAINST CCL4 INDUCED HEPATOXICITY IN MALE ALBINO RATS

Emeji Roseline*, Boisa N. and Tamuno-Emine D. G.

ABSTRACT

Viscum album (mistletoe) was used in traditional medicine for the treatment of various disorders, including hepatic disorders. The present study was aimed at evaluating efficacy of viscum album in protecting rat liver against CCL4-induced liver injury. Biochemical parameters and histological structure were assessed and used as a measure of hepatoprotective potential. The experimental animals (15 male wistar albino rats) weighing between 100-120g were randomly divided into 3 groups. Each group comprised 5 rats and was labeled as group 1, 2 and 3. Group 1 (negative control) animals were administered saline orally daily for 6 weeks (1ml volume per kg body weight) while group 2 (CCL4group) animals were administered CCL4 mixed with olive oil as vehicle in 1:1 ratio (3ml/kg body weight). In case of hepatoprotective study (that is post treatment of rats) with extract of the herbal plants (500mg/kg daily for each herb; and 250mg/kg daily for the combination of herbal extracts) administered orally for 6 weeks decreased (P

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