Abstract

Sagar Kishor Savale*

ABSTRACT

Aceclofenac is an analgesic and anti-inflammatory drug that reduces fever, pain, and inflammation in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. Aceclofenac has higher anti-inflammatory action than conventional NSAIDs. Development of microspheres is a promising technology for controlled release and drug targeting. Various types of microspheres such as bio-adhesive, magnetic, floating, radioactive and polymeric microspheres are developed for various purposes. Microspheres occupied a central place in novel drug delivery, it can targeted and localized drug delivery system. This Aceclofenac Microsphere is Prepared by using Spray drying Technique in which release rate of drug is mainly depends on formulation composition (Eudragit RS 30 D and Ethyl Cellulose (1:2 ratio)). Formulated microspheres were characterized for particle size, encapsulation efficiency and In vitro studies. The optimum drug-to-polymer ratio and feed flow rate is responsible for higher percent yield, smaller particle size and maximum encapsulation efficiency.