FORMULATION AND IN VITRO EVALUATION OF GASTRO RETENTIVE FLOATING TABLETS OF GLIPIZIDE
P. Sowjanya, Jennayikode Shiva*, Sujatha Banavath, Kalyankar Manasvi Jyothirmai, Ragya Eslavath, R. Suthakaran and Goli Venkateshwarlu
ABSTRACT
The purpose of present investigation was to develop and evaluate floating drug delivery system of an oral hypoglycemic agent. The floating tablets of Glipizide were prepared by using HPMC K4M, HRMCK100, Xanthan gum polymers. The pre compression and post compression parameters were performed as per pharmacopoeial standards. The tablets were prepared by direct compression method. Dissolution measurements were carried out in a (USP) dissolution testing apparatus the invitro buoyancy studies were performed and Compatibility study was performed by FTIR. The compatibility study of the prepared Glipizide floating tablets confirms that there is no interaction between the drug and polymers used.
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