World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 6.842

ICV : 78.6

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SJIF Impact Factor: 6.842

Abstract

A NEW TECHNICAL METHOD FOR GLECAPREVIR AND PIBRENTASVIR IN COMBINED DOSAGE FORMS USING NON POLAR HPLC

NDVR Saradhi*, Dr. Rakesh Kumar Jat, Dr. M. Venkata Reddy

ABSTRACT

Antiviral drugs are in combined dosage forms may effectively used to treat hepatitis infections caused by the virus by competitive binding with NS3/4a and NS5 part of virions and make relief from the infection. The method was developed by using Methanol, TEA and Acetonitrile in 55:25:20 v/v ratios as mobile phase and Altima C18 stationary phase having 150*4.6 mm 5? particle sizes. The HPLC is waters - 2695 with PDA equipped and empowered with soft ware for integration of data. The Glecaprevir (GLEC) and Pibrentasvir (PIBR) were observed at 225 nm with retention of 3.53 and 2.10 min respectively. This technical procedure was evaluated as per the guidelines of the ICH for its sensitivity, selectivity, and Linearity correlation was found to be in 0.999. The accuracy and LOD, LOQ were found in 0.2, 2.3 mcg/ml and 0.8, 7.04 mcg/ ml respectively. Robustness and ruggedness are also approved. The study is continued for its stability testing to know about the drug with various corrosive environmental factors.

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