IN SILICO STUDIES ON DENGUE AND CHIKUNGUNYA VIRAL PROTEINS WITH SELECTED EMBLICA OFFICINALIS (AMLA) LEAVES CONSTITUENTS
Pavithra K., Nisha R., Rameen Taj S., Shethal V. Rao, Tulasi D. P., *Dr. Balasubramanian Sathyamurthy
ABSTRACT
Dengue and chikungunya virus contains seven proteins, which are considered to be the most effective for drug designing. Recent studies have shown that these proteins can effectively cause the inactivation of dengue and chikungunya disease in humans. Phytochemicals present in Emblica offiinalis are found to have anti-bacterial and anti-cancer properties. In our study, the binding efficiency of 4 compounds that is present in the Emblica officinalis with all the fourteen proteins was performed through Insilico methods. By our virtual screening and molecular docking result, we found that the Benzoic acid, 3,4,5-trihydroxy- have highest binding affinity with the proteins and we also predicted the binding site amino acid residues and the type of hydrogen bonding.
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