Abstract

Dr. Sribna Valentyna*, Kaleynykova Oksana, Aliyeva Tamila, Karvatskiy Igor, Voznesenskaya Tetyana, Blashkiv Taras

ABSTRACT

Premature ovarian failure affecting women under 40 years of age, is actively studied. This disease is becoming widespread due to the delay in maternity and is currently a medical and social problem. Until now, it is unclear whether the development of the autoimmune process is a primary cause of this disease or it is the result of chronic pathology. Glomerulonephritis represents a serious problem for reproductive health of women. The reproductive function may be affected by both, the glomerular disease itself and glucocorticoid and cytostatic therapy. Among the known antioxidants, resveratrol has received numerous approvals when used in various disease patterns, including oocytes. The effect of resveratrol on reproductive function in women under conditions of experimental glomerulonephritis has not been studied yet, which makes this research relevant today. The aim of the given study was to estimate the effect of resveratrol treatment on the female reproductive function under conditions of experimental glomerulonephritis. Experiments have been conducted on white laboratory mice: females and males. Experimental glomerulonephritis was achieved by immunization of mice of the first generation with a kidney antigen suspension derived from a parent. Resveratrol (50 mg/kg, Sigma-Aldrich, USA) was injected intraperitoneally 4 times. It has been shown for the first time that under conditions of experimental glomerulonephritis the treatment of resveratrol increase meiotic maturation, decrease apoptotic and necrotic death of the follicular environment of oocytes and a decrease of the post-implantation mortality rate of embryos in mice.