Abstract

D. K. Awasthi*, Shefali Gupta and Gyanendra Awasthi

ABSTRACT

The transition metals are compounds where the compound has an incomplete d sub shell i.e. Mn (II), Fe (II),Fe (III) etc and due to their instability in structure it has variable oxidation number as well as unstable electronic configuration which modulate the variable redox system present inside the biological system and it exhibit different oxidation states and can interact with a number of negatively charged molecules. This aactivity of transition metals has started the development of metal based drugs with promising pharmacological application and may offer unique therapeutic opportunities and show remarkable therapeutic success of anticancer drugs such as cisplatin, carboplatin and oxaliplatin, metallodrugs have also shown promising results in the treatment of diseases other than cancer also. They have been developed to treat/cure a variety of ailments viz. diabetes, ulcer, rheumatoid arthritis, inflammatory and cardiovascular diseases etc. Phytoconstituent like Curcumin has keto-enol form transformation property and utilising that property in the open chain configuration of enolic form metal ion will attach and its gives a structure of chelates where curcumin will act as ligand. This chelate can be synthesized in different proportion depending on the chemical nature of metal central cation as well also.