Abstract

Ch. Anitha*, G. A. Sravya Malika, K. Rani Samyuktha, S. K. Sharmila, S. Vara Prasad and P. Srinivasa Babu

ABSTRACT

Background: The fixed dose combinations (FDCs) of muscle relaxants, non-steroidal anti-inflammatory drugs and paracetamol are commonly prescribed in the treatment of acute lower backache with muscle spasms Aim: The present study was undertaken with the aim of comparing the safety and efficacy of FDCs of thiocolchicoside, aceclofenac & paracetamol versus chlorzoxazone, aceclofenac and paracetamol in patients with acute lower backache associated with muscle spasm. Materials and Methods: A total of 25 patients ?20 years having low back pain of ?7days duration were randomly divided into two groups. Group A was prescribed chlorzoxazone (500 mg) + aceclofenac (100 mg) + paracetamol (325mg) while Group B was prescribed thiocolchicoside (4 mg) + aceclofenac (100 mg) + paracetamol (325 mg) orally twice daily for 7 days. Severity of pain at rest and on movement was recorded using visual analogue scale. Muscle spasm was evaluated by hand-to-floor distance. Readings were noted on day 1 (baseline) and day 7. Results: There was statistically significant reduction in severity of pain and muscle spasm on day 0 and day 7 in both groups. There was no statistically significant difference in pain relief and muscle spasm among the treatment groups but clinically showed better improvement in the Group A. The adverse drug reactions occurring during study showed a statistically significant better safety profile in the Group B than Group A. Conclusion: These findings confirm that FDC of thiocolchicoside, aceclofenac and paracetamol is a preferred option for patients with lower backache pain associated with muscle spasm.