Abstract

Sandeep Chaudhary*, S. Satyanandam, M. A. Saleem and Sushil Sah

ABSTRACT

The main investigation of the study was to formulate super-disintegrating tablets which dissolve in mouth that contains Ibuprofen by using sodium starchglycolate, Croscarmellose sodium, Crospovidone and evaluate them for drug release. Various preparations were made by using super-disintegrating agents (2 mg, 4 mg, 6 mg, 8 mg & 10 mg). All the nine formulations are having good flow properties and are prepared by direct compression technique. Compatibility studies were conducted by using FTIR and all the excipients used in the formulation were compatible with the drug. The rate of dissolution as well as the drug release was found to be varying with the concentration of drug and polymer. The formulation with 10 mg i.e (F6) was found to be the best formulation among all the formulation.