Abstract

Praneeth Chandaluri*, Ramesh Ganpisetti*, Nally Suman Raj, Chandrakanth. A and A. J Rocky

ABSTRACT

Haloperidol, marketed under the trade name Haldol among others, is a typical antipsychotic medication. Indications Acute and chronic psychotic disorders including: schizophrenia, manic states, druginduced psychoses. Patients with schizophrenia who require long-term parenteral (IM) antipsychotic therapy. Also useful in managing aggressive or agitated patients. Tourette’s syndrome. Action Alters the effects of dopamine in the CNS. Also has anticholinergic and alpha-adrenergic blocking activity. Contraindications/Precautions Contraindicated in: Hypersensitivity; Angle-closure glaucoma; Bone marrow depression; CNS depression; Parkinsonism.Adverse Reactions/Side Effects CNS, SEIZURES, extrapyramidal reactions, confusion, drowsiness, restlessness, tardive dyskinesia. EENT: blurred vision, dry eyes. Resp: respiratory depression. For maintenance treatment of schizophrenia, an international consensus conference recommended a reduction dosage by about 20% every 6 months until a minimal maintenance dose is established. Topical formulations of haloperidol should not be used as treatment for nausea because research does not indicate this therapy is more effective than alternatives.