Abstract

Amruthavalli G. V.*, Satarupa Mukherjee, Aruna V. and Gayathri R.

ABSTRACT

Background: The present study deals with the importance of herbs in fortifying the anti-dandruff efficacy of Climbazole and Zinc Pyrithione (ZPTO) through a novel mechanism. The synergy between the herb and the synthetic anti-dandruff agents not only curb dandruff but also prevent drug resistance. The synergy may pose confusion to the pathogen to identify the target molecule and there by develop drug resistance. This is the first study to the best of our knowledge unravel the scientific mystery behind herb – synthetic molecule synergy for prognosis and drug resistance. Method: Zone of inhibition and minimum inhibitory concentration was studied for the individual test materials and market samples. Market samples also tested in different water types by zone of inhibition. A pilot scale study on market products was conducted in human volunteers to understand the aesthetics and hair properties after use. Results: All the studies prove the anti-dandruff activity of the Verdura anti-scaling scalp shampoo and other test samples. The stable efficacy of the Verdura was proven when studied in different waters. Conclusion: Verdura anti scaling scalp shampoo with two anti-dandruff agents Climbazole and Zinc pyrithione along with herbal extracts shows the better activity (at the tested concentrations) and also have superior conditioning benefits.