Abstract

Vijayalakshmi S.*, Farheena M. I., Chithira A. and Mohankumar A.

ABSTRACT

Recurrently blood stream infection causing Pseudomonas aeruginosa is frequent pathogen associated with hospital acquired infections exhibiting intrinsic resistance to numerous antibiotics. A total of 50 isolates of Pseudomonas aeruginosa were isolated from blood cancer patient from primary healthcare center around Tirupur District and the isolates were identified using phenotypic characterization. Further, the microbial sensitivity testing was done using Disk Diffusion Test (DDT). In this study Pseudomonas aeruginosa demonstrated marked resistant against different class of antibiotics. Among different class of antibiotics the maximum resistant activity was observed in Vancomycin 99% followed by minimum resistant was observed in Levofloxacin 1%. This result proved the greatest world killer (Pseudomonas aeruginosa) is responsible for the demise of cancer patient annually. It indicated that the impact of blood stream infection causing Pseudomonas aeruginosa is greater significance in developing countries. So for the management of disease is troubled by simultaneous resistance to multiple drug representing that there is severe and pressing need to progress new therapeutics that can alarmed drug resistance. Recurrently, the marine brown algae has been considered for varied and plentiful source of potent bioactive chemical such as sliver nanoparticle (AgNo3) from Bacillus cereus which can be represented as drug of choice. The nanoparticles showed appreciable activity at all tested concentrations (50, 100 and 150?l). Thus, it is concluded that the present study designed to determine the synthesis of sliver nanoparticle (AgNo3) from brown algae which serve as a promising antibacterial agent against BSI.