Abstract

K. Prasanna Kumari*, R. Sarvanan, D. Dhachinamoorthi

ABSTRACT

Mirtazapine is an antidepressant introduced by Organon International in 1996 used for the treatment of moderate to severe depression. It is extensively metabolized by liver and having oral bioavailabity of 50%. To improve the oral bioavailability of Mirtazapine oral disintegrating tablets were formulated using different natural and synthetic super disintegrants. In the present work, Oral disintegrating tablets of Mirtazapine were prepared by direct compression method using superdisintegrants such as crosspovidone, SSG and Ac-Di-Sol. The dispersion time of tablets were reduced with increase in the concentration of superdisintegrants. From the results obtained, it was concluded that Ac-Di-Sol was found to be the best among the superdisintegrants, the highest drug release was found to be 98.52% in F4 formulation at the end of 20 min.