Abstract

Rajesh L. Dumpala* and Dr. Akruti Khodakiya

ABSTRACT

Poorly water soluble drug candidates are becoming more prevalent and it has been estimated that 40-50% of drug molecules are poorly soluble in aqueous media or have a low permeability which does not allow for their adequate absorption from gastrointestinal tract following by oral administration. Formulation scientists have to adopt different strategies to enhance their absorption. Lipid formulations are seen to be a promising approach to combat the challenges and especially self-microemulsifying drug delivery(SMEDDS) system approach are used to increase the absorption of poorly absorbed drug which ultimately increased there bioavability. The liquid SMEDDS are converted to solid SMEDDS by using liquid solid compact technique in which amount of carrier materials are calculated that maximum amount of non-volatile liquid can be retained inside its bulk [w/w] while maintaining an acceptable flowability.