Abstract

OKE Olusegun Taiwo*, EMELIKE Okechuwku Felix, OYEDEJI Samuel Oyewole, OBAZEE Docars Yetunde

ABSTRACT

This study was carried out to assess the impact of nephrotic syndrome on some blood coagulation and biochemical parameters and to see if there is any correlation between the coagulation and biochemical parameters estimated among these group of patients some part of South West Nigeria. Sixty (60) patients with nephrotic syndrome formed the subjects for this study, while sixty (60) apparently healthy individual served as the control population. The subjects were between the ages of 3 – 60 years. Out of sixty (60) patients recruited for this work, 34(56.67%) were males while 26(43.33%) were females. Whole blood was collected from all the subjects and control to determine some of their coagulation (PT, PTTK and Pletelet) and Biochemical Parameters as well (Total Protein, Albumin, Urea and Creatinine). Also 24 hour urine was collected into 1ml of 1% normal HCL from each of the subjects and random urine samples from the control subjects for urinary protein estimation using standard methods. Data generated were analyzed using SPSS standard deviation, correlation and t-test. P?0.05 is considered statistically significant. The results of this work showed that males were more affected than the females and the ratio of male to female was 1.9:1. The average total serum proteins of subject worked on was 55.70± 13.5g/L control subject was 70.59±11.38g/L (p>0.05), urinary protein 6.66±2.64g/L, control 0.72±0.28g/L (p