Abstract

Dr. Bhupendra Kumar Mandawat and Dr. Preetam Singh Mandawat*

ABSTRACT

Background: Tuberculosis (TB) is thought to be one of the oldest human diseases and the history is almost as old as mankind. India has the highest TB burden accounting for one-fifth of the global incidence and nearly 40% of the Indian population is infected with the TB bacillus. In India and other developing countries TB lymphadenitis is the most common form of extrapulmonary TB. Objectives: The aim of this study was to compare FNAC and ZN staining findings of clinically suspected tuberculous lymphadenitis cases. This study was undertaken to evaluate cytomorphological patterns of tuberculous lymphadenitis and to correlate the acid-fast bacilli (AFB) positivity. Methodology: The present study was conducted in the clinical laboratory of NMCH at Govt. Medical College, Kota from period of 1st January, 2018 to 31th December 2018 to comparative evaluate the detection of Tuberculous lymphadenitis by FNAC and ZN staining. Result: Total 463 cases of lymphadenopathy were included in our study. Tuberculous lymphadenitis accounted for 102 (22.03%) cases, among which AFB was present in 68 (66.67%) cases. The maximum incidences of cases were seen in the age range of 21-30 years (39.23%). A slight Female preponderance with a female to male ratio of 1.49:1 was noted. The most common group of lymph nodes affected was cervical (75.49%). Maximum AFB positivity was found in smears with epithelioid granuloma with caseous necrosis (24.51 %). Conclusion: FNAC is an assay that has high sensitivities, is optimally selected, efficient, easy to perform, and minimally invasive procedure to diagnose TB lymphadenitis. Supplementation of ZN stain with FNAC increases the rates of diagnosis. Regardless of the presence of granuloma, ZN stain must be employed whenever infective pathology is suspected.