World Journal of Pharmaceutical
and Medical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
ISSN 2455-3301
IMPACT FACTOR: 6.842

ICV : 78.6

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SJIF Impact Factor: 6.842

Abstract

SYNTHESIS AND BIOLOGICAL EVALUATION OF 1,4 DIHYDROPYRIDINES DERIVATIVES

Pradeep Kumar L.*, Dr. Sangamesh B. Puranik, Dr. Ashok Kumar B. S., Sridhar S. M.

ABSTRACT

Heterocyclic chemistry is of great importance to the medicinal chemists because of their drug utility. Large number of heterocyclic compounds being used as therapeutic agentsand these compounds are also essential for the human life.1, 4-Dihydropyridines are associated with broad spectrum of biological activities. A series of new Schiff bases containing the Hantzsch 1,4-dihydropyridine skeleton (1a-1g) has been synthesized byreaction of an appropriate aldehyde with 1, 4-dihydro-4-(substituted phenyl)-2,6-dimethylpyridine-3,5-dicarbohydrazide. The synthesized compounds were then characterized by TLC, melting point determination, IR, 1H-NMR.

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