Abstract

M. N. Tillashaykhov*, L. T. Gaziev and A. J. Kakhkharov

ABSTRACT

In terms of incidence among malignant neoplasm, renal cell cancer (RCC) ranks tenth in the world and firmly holds the third place among malignant neoplasm of the genitourinary system.[1,2] In the structure of cancer incidence in the world population, RCC accounts for 2-3% of all malignant neoplasm, with the highest incidence in developed countries.[3] In Russia, in 2017, RCC was first diagnosed in 13556 patients. The standardized incidence rate was 16.87 per 100,000 populations, and the increase in incidence over 10 years was 42.63%. In terms of the rate of increase in the incidence of RCC, it is second only to prostate and thyroid tumors.[4] In Uzbekistan, the incidence is 2.2 per 100 thousand populations.[5] RCC is characterized by a fairly variable and unpredictable clinical course, which is due to the genetic heterogeneity and morphological diversity of this group of tumors.[6] Despite the fact that in recent years there has been an improvement in the detection of the process, more frequent detection of small tumors and early stages, the mortality rate from RCC has not undergone significant changes.[7] Therefore, the identification of factors that make it possible to make an individual prognosis and determine the optimal treatment strategy for a RCC patient is one of the most important tasks of modern oncourology.[8] Of the many prognostic parameters studied so far, the stage of the tumor when it is detected is the most predictive in relation to the probable course of the disease.[9] In the era of development of minimally invasive and ablative methods of treatment, new forms of targeted therapy and new views on the molecular mechanisms of development and progression of RCC, the identification of factors that make it possible to make an individual prognosis and determine the optimal treatment strategy for a patient with renal cell cancer is one of the most important tasks of modern oncourology.[10] Therefore, it seems relevant to conduct a study aimed at identifying the influence of various clinical and morphological parameters of renal cell cancer on survival rates.